miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction

Figure 8

miR-657 promotes tumor growth in vivo. (a and b) miR-657 overexpression tumors were significantly larger than those of control mice, while the miR-657 suppression tumors were reduced in comparison with the negative control mice. (c) miR-657 expression levels in the different tumors were confirmed by RT-qPCR. (d and e) Overexpression of miR-657 promoted cell growth and suppressed apoptosis, while blocking of miR-657 expression reduced cell growth and induced cell apoptosis in vivo. (f) Western blot results also showed overexpression of miR-657 suppressed SRCIN1 and E-cadherin levels and enhanced N-cadherin, Vimentin, Slug, and Snail expressions in xenograft tumors.

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