Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma

<div>S100A4 affects proliferation and migration of glioma cells. (a) qRT-PCR and (b) western blot analysis of S100A4 knockdown efficiency in LN229 cells. (c) Analysis of proliferation of control and S100A4-deficient LN229 cells by CCK8 assay. (d) Representative images and (e) statistical analysis of EdU assay in control and S100A4-deficient LN229 cells. (f) Representative images and (g) statistical analysis of cell migration assay in control and S100A4-deficient endothelial cells at the indicated times. <span class="nowrap"><svg height="9.2729pt" id="M27" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 52.4989 9.2729" width="52.4989pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 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Disease Markers

fig11

Figure 11

Figure 11: Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma 