Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma

<div>Immune and stromal signatures of gliomas. Ridge plot showing the immune, ESTIMATE, and stromal scores of different risk-score subgroups in the (a) CGGA cohort and (b) TCGA cohort, respectively. Correlation analysis of risk score with immune, ESTIMATE, and stromal scores in the (c) CGGA cohort and (d) TCGA cohort, respectively. Matrix bubble displaying the correlation analysis of the eight S100 family genes with the infiltration levels of T cell CD4+ naïve, Tregs, NK activated, monocyte, neutrophil, and macrophages M0/M1/M2 in (e) the CGGA cohort and (f) the TCGA cohort. <span class="nowrap"><svg height="9.2729pt" id="M12" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 52.4989 9.2729" width="52.4989pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 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Disease Markers

fig6

Figure 6

Figure 6: Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma 