Liraglutide Alleviates Diabetic Atherosclerosis through Regulating Calcification of Vascular Smooth Muscle Cells

Figure 1

LIRA inhibits the osteogenic transformation of VSMC in the thoracic aorta of DM rats. (a) IHC showed the expression of SMα-actin in the rat thoracic aorta (400x). In group DM + AS, 0 months vs. 2 months () and 2 months vs. 4 months (). In months 2 and months 4, DM + AS vs. control () and DM + AS + LIRA vs. DM + AS (); in group DM + AS, 0 months vs. 2 months () and 2 months vs. 4 months (). Protein expression of (b) SMα-actin, (c) OPN, and (d) Cbfα-1. Data were from three independent experiments expressed as deviation. In month 2 and month 4, DM + AS vs. control () and DM + AS + LIRA vs. DM + AS (). In group DM + AS, 0 months vs. 2 months () and 2 months vs. 4 months (). vs. control; vs. DM + AS.

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