Association of Plasma Anion Gap with 28-Day Inhospital Mortality and 1-Year Mortality of Patients with Alcohol Use Disorder at ICU Admission: A Retrospective Cohort Study

Table 3

Time-varying HRs and 95% CI for AG in association with 1-year mortality from Cox models.

	Nonadjusted		Adjusted I		Adjusted II
	HR (95% CI)		HR (95% CI)		HR (95% CI)
AG	1.016 (1.013, 1.019)	<0.0001	1.018 (1.015, 1.021)	<0.0001	1.010 (1.007, 1.013)	<0.0001
AG^Quintile
	1		1		1
	1.073 (0.933, 1.234)	0.3230	1.083 (0.941, 1.247)	0.2657	1.037 (0.898, 1.196)	0.62276
	1.103 (0.969, 1.256)	0.1370	1.129 (0.992, 1.286)	0.06705	1.091 (0.955, 1.246)	0.20161
	1.221 (1.074, 1.388)	0.0022	1.243 (1.093, 1.413)	0.000915	1.201 (1.052, 1.371)	0.006585
	1.378 (1.210, 1.569)	<0.0001	1.409 (1.237, 1.605)	<0.0001	1.309 (1.149, 1.492)	<0.0001
AG for trend	1.090 (1.067, 1.114)	<0.0001	1.097 (1.073, 1.120)	<0.0001	1.067 (1.045, 1.090)	<0.0001

Abbreviations: AG: anion gap; CI: confidence interval; HR: hazard ratio. Adjusted I for age, gender, and ethnicity. Adjusted II for age, ethnicity, gender, time in hospital, ventilation, vasopression, sepsis, cerebrovascular disease, peptic ulcer disease, mild liver disease, renal disease, severe liver disease, and metastatic solid tumor. Reference group:  mmol/L.