Association of Polymorphisms in NHEJ Pathway Genes with HIV-1 Infection and AIDS Progression in a Northern Chinese MSM Population

Table 4

Associations between 22 SNPs in NHEJ genes and clinical features of AIDS.

Gene	Gene polymorphisms	Genotype	CD4+ T lymphocyte count^a			OR (95% CI)	Clinical stage^b			OR (95% CI)
			<350 cells/μl	>350 cells/μl			Phase III+IV	Phase I+II
XRCC7	rs7830743	GG+AG	37	35	0.550	0.858 (0.519-1.418)	29	43	0.438	0.817 (0.491-1.361)
		AA	223	181			184	223
	rs7003908	CC+CA	125	92	0.232	1.248 (0.868-1.795)	100	118	0.572	1.110 (0.773-1.594)
		AA	135	124			113	148
XRCC6	rs5751129	CC+CT	49	39	0.825	1.054 (0.662-1.679)	40	48	0.837	1.050 (0.660-1.671)
		TT	211	177			173	218
	rs2267437	GG+CG	118	82	0.103	1.358 (0.940-1.961)	95	107	0.335	1.196 (0.831-1.723)
		CC	142	134			118	159
	rs132770	AA+AG	38	31	0.908	1.031 (0.617-1.722)	27	43	0.282	0.752 (0.448-1.264)
		GG	220	185			187	224
	rs132774	CC+CG	50	39	0.743	1.081 (0.679-1.719)	40	49	0.920	1.024 (0.645-1.627)
		GG	210	177			173	217
XRCC5	rs828907	TT+GT	104	86	0.967	1.008 (0.697-1.457)	92	99	0.185	1.283 (0.888-1.853)
		GG	156	130			121	167
	rs705649	AA+GA	105	85	0.819	1.044 (0.722-1.509)	92	99	0.185	1.283 (0.888-1.853)
		GG	155	131			121	167
	rs16855458	AA+AC	109	69	0.025	1.538 (1.054-2.243)	87	92	0.160	1.306 (0.900-1.895)
		CC	151	147			126	174
	rs3770502	TT+CT	81	61	0.489	1.150 (0.774-1.708)	66	76	0.499	1.146 (0.772-1.700)
		CC	179	155			144	190
	rs9288516	AA+TA	183	145	0.445	1.164 (0.789-1.717)	144	185	0.649	0.914 (0.620-1.347)
		TT	77	71			69	81
	rs3835	AA+AG	36	35	0.495	0.839 (0.506-1.390)	33	39	0.804	1.066 (0.645-1.763)
		GG	222	181			181	228
	rs1051677	CC+TC	83	61	0.384	1.192 (0.803-1.768)	68	77	0.481	1.151 (0.778-1.703)
		TT	177	155			145	189
	rs2440	GG+AG	127	113	0.451	0.870 (0.607-1.249)	96	136	0.767	0.947 (0.660-1.358)
		AA	133	103			107	130
XRCC4	rs6869366	GG+GT	36	20	0.124	1.575 (0.883-2.811)	23	33	0.587	0.855 (0.485-1.505)
		TT	224	196			190	233
	rs2075685	TT+GT	77	80	0.087	0.715 (0.487-1.050)	62	95	0.126	0.739 (0.502-1.089)
		GG	183	136			151	171
	rs10040363	GG+AG	72	66	0.510	0.875 (0.588-1.302)	59	79	0.613	0.902 (0.605-1.345)
		AA	187	150			154	186
	rs963248	TT+TC	136	132	0.054	0.698 (0.484-1.007)	114	155	0.298	0.825 (0.574-1.186)
		CC	124	84			99	111
	rs35268	CC+TC	70	51	0.409	1.192 (0.786-1.808)	60	61	0.191	1.318 (0.872-1.992)
		TT	190	165			153	205
	rs1056503	TT+TG	128	118	0.241	0.805 (0.561-1.156)	107	140	0.602	0.909 (0.633-1.303)
		GG	132	98			106	126
LIG4	rs1805388	AA+AG	87	69	0.726	1.071 (0.729-1.574)	81	77	0.036	1.506 (1.027-2.209)
		GG	173	147			132	189
	rs1805389	AA+AG	52	39	0.591	1.135 (0.716-1.799)	48	45	0.124	1.429 (0.907-2.249)
		GG	208	177			165	221

Italicized values indicate statistical significance. ^aThe CD4+ T lymphocyte counts were divided into two groups: category 1, <350 cells/μl, and category 2, >350 cells/μl. ^bClinical stage: category A, clinical phase III+IV, and category B, clinical phase I+II.