Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK

Figure 5

PTPRR significantly reduced MuSK-dependent AChR clustering in C2C12 myotubes. (a) C2C12 myoblasts were stably transfected with PTPRR, DA mutant, or empty vector plasmids. The efficiency of overexpression PTPRR was verified by western. (b) Compared with the C2C12 transfected with DA mutant or empty vector, C2C12 transfected with PTPRR had markedly reduced AChR clusters. White arrowheads indicate AChR clusters. (c) Quantification of AChR clusters ≥5 μm in length from (b). The data were obtained from at least three experiments. Data were shown as . NS: no significant difference. , , and .

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