Crosslinking-Induced Corneal Endothelium Dysfunction and Its Protection by Topical Ripasudil Treatment

<div>CXL irradiation causes DNA damage in corneal endothelial cells. (a) Representative confocal images of the mouse corneal endothelium with 8-OHdG staining at 36 h after CXL treatment. (b) Representative confocal images of the mouse corneal endothelium with <i>γ</i>-H2AX staining at 36 h after CXL treatment. (c) Mean immunofluorescence intensity of 8-OHdG in endothelial cells. (d) Mean immunofluorescence intensity of <i>γ</i>-H2AX in endothelial cells. 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Disease Markers

fig5

Figure 5

Figure 5: Crosslinking-Induced Corneal Endothelium Dysfunction and Its Protection by Topical Ripasudil Treatment 