Ginsenoside Rb1 Modulates the Migration of Bone-Derived Mesenchymal Stem Cells through the SDF-1/CXCR4 Axis and PI3K/Akt Pathway

<div>The PI3K inhibitor suppressed the migration process of BMSCs. BMSCs were pretreated with LY294002 for 1 hour at 37°C prior to the administration of ginsenoside Rb1. (a) Representative images of the wound-healing assay in different groups, and wound sites were observed and photographed at 0 and 24 h (×200 original magnification). (b) Representative images of the Transwell assay in different groups, and cells migrated from the upper chamber to the bottom surfaces were stained with crystal violet and observed under a microscope (×200 original magnification). (c) Quantitative results of the wound-healing assay. (d) Quantitative results of the Transwell assay. Tests were performed at least three times. 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Disease Markers

fig6

Figure 6

Figure 6: Ginsenoside Rb1 Modulates the Migration of Bone-Derived Mesenchymal Stem Cells through the SDF-1/CXCR4 Axis and PI3K/Akt Pathway 