Cell-Free DNA Variables including Gene Mutations in CA15-3 Normal Breast Cancer Reflect Prognosis

Table 3

Association between concentration, integrity index, CNV index, and clinical characteristics of patients () (, (, )).

Characteristics	Concentration (ng/ml)		Integrity index		CNV index
Age at diagnosis (years)
≤50		0.593	0.28 (0.12, 0.61)	0.134		0.310
>50			0.21 (0.08, 0.36)
ER/PR/HER2 status at diagnosis
TNBC		0.080		0.695		0.533
HER2^+ (any ER/PR)
HER2^- (ER or/and PR^+)
Tumor size (cm)
≤2		0.446		0.658		0.226
>2
Tumor stage
I/II	13.76 (8.94, 18.85)	0.002		0.141	1.03 (0.90,1.18)	0.278
III/IV	25.02 (12.67, 35.30)				1.07 (0.92,1.55)
Metastatic status
No	12.72 (9.06, 18.18)	0.001		0.123		0.090
Yes	26.16 (15.25, 42.83)
Distant metastatic status
No	12.94 (9.41, 19.53)	<0.001		0.364		0.008
Yes	33.62 (22.95, 41.09)

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