Cell-Free DNA Variables including Gene Mutations in CA15-3 Normal Breast Cancer Reflect Prognosis

Table 4

Association between gene mutation status and clinical characteristics of patients ().

Characteristics	SNV				TP53 mutation				PIK3CA mutation				KRAS mutation
	No	Yes			No	Yes			No	Yes			No	Yes
Age at diagnosis (year)
≦50	16	16	0.210	0.647	23	9	3.171	0.075	25	7	0.743	0.389	31	1	2.916	0.088
>50	20	16			32	4			31	5			29	7
ER/PR/HER2 status at diagnosis
TNBC	2	4	1.663	0.435	4	2	2.388	0.303	6	0	3.152	0.207	4	2	3.061	0.216
HER2^+ (any ER/PR)	9	5			13	1			14	0			13	1
HER2^- (ER or/and PR^+)	25	23			38	10			36	12			43	5
Tumor size (cm)
≤2	16	15	0.040	0.841	25	6	0.002	0.964	27	4	0.882	0.348	27	4	0.071	0.79
>2	20	17			30	7			29	8			33	4
Tumor stage
I/II	26	15	4.546	0.033	36	5	3.200	0.074	34	7	0.023	0.878	37	4	0.401	0.526
III/IV	10	17			19	8			22	5			23	4
Metastatic status
No	21	15	0.893	0.345	33	3	5.754	0.016	31	5	0.743	0.389	32	4	0.031	0.859
Yes	15	17			22	10			25	7			28	4
Distant metastatic status
No	30	25	0.297	0.586	48	7	7.598	0.006	44	11	1.096	0.295	49	6	0.203	0.652
Yes	6	7			7	6			12	1			11	2

SNV: single nucleotide variant. , .