Cell-Free DNA Variables including Gene Mutations in CA15-3 Normal Breast Cancer Reflect Prognosis

Table 7

Univariate/multivariate Cox proportional regression survival analysis.

Characteristics	Univariable analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Age at diagnosis (year)
≤50	1.000
>50	1.800	0.610-5.309	0.287
Tumor size (cm)
<2	1.000
≥2	0.799	0.342-1.862	0.603
Stage
I/II	1.000			1.000
III/IV	1.091	0.376-3.165	0.873	0.346	0.088-1.355	0.127
ER/PR/HER2 status at diagnosis
TNBC	1.000
HER2+ (any ER/PR)	0.367	0.071-1.900	0.232
HER2- (ER or/and PR+)	0.348	0.090-1.340	0.125
cfDNA concentration
Low	1.000			1.000
High	10.204	2.291-45.437	0.002	5.786	1.101-30.407	0.038
cfDNA integrity
Low	1.000
High	0.361	0.114-1.144	0.083
CNV
Low	1.000
High	2.558	0.713-9.182	0.150
SNV
No	1.000			1.000
Yes	6.042	1.666-21.904	0.006	2.580	0.416-16.011	0.309
TP53 mutation
No	1.000			1.000
Yes	7.414	2.528-21.741	0.001	2.771	0.699-10.987	0.147

. Omnibus test: .