Expression and Clinical Significance of lncRNA NEAT1 in Patients with Spinal Tuberculosis
Table 1
Baseline clinical characteristics.
Parameters
Overall cohort ()
Cured ()
Relapse ()
value
Age (years)
<60
78 (65)
73 (60.8)
5 (4.2)
0.718
≧60
42 (35)
38 (31.7)
4 (3.3)
Sex
Male
63 (52.5)
61 (50.8)
2 (1.7)
0.084
Female
57 (47.5)
50 (41.7)
7 (5.8)
Systemic toxicity symptoms
Yes
52 (43.3)
47 (39.2)
5 (4.2)
0.499
No
68 (56.7)
64 (53.3)
4 (3.3)
Back pain
Yes
90 (75)
85 (70.8)
5 (4.2)
0.225
No
30 (25)
26 (21.7)
4 (3.3)
Radiating pain
Yes
67 (55.8)
60 (50.0)
7 (5.8)
0.296
No
53 (44.2)
51 (42.5)
2 (1.7)
ASIA scale
A
5 (4.2)
4 (3.3)
1 (0.8)
0.195
B
10 (8.3)
8 (6.7)
2 (1.7)
C
21 (17.5)
19 (15.8)
2 (1.7)
D
33 (27.5)
31 (25.8)
2 (1.7)
E
51 (42.5)
49 (40.8)
2 (1.7)
Locations of the lesions
Thoracic segment
54 (45.0)
48 (40.0)
6 (5.0)
0.132
Lumbar segment
60 (50.0)
58 (48.3)
2 (1.7)
Both
6 (5.0)
5 (4.2)
1 (0.8)
Segments of the lesions
2 segments
59 (49.2)
53 (44.2)
6 (5.0)
0.319
≧3 segments
61 (50.8)
58 (48.3)
3 (2.5)
Paraspinal abscesses
Yes
62 (51.7)
58 (48.3)
4 (3.3)
0.737
No
58 (48.3)
53 (44.2)
5 (4.2)
TB history
Yes
43 (35.8)
39 (32.5)
4 (3.3)
0.720
No
77 (64.2)
72 (60.0)
5 (4.2)
Anti-TB treatment
2 weeks
60 (50)
58 (48.3)
2 (1.7)
0.163
>2weeks
60 (50)
53 (44.2)
7 (5.8)
CRP (mean, SD) (mg/l)
0.963
ESR (mean, SD) (mm/h)
0.666
IL-6 (median, IQR) (pg/ml)
11.58 (10.27-12.26)
10.35 (9.71-12.09)
11.59 (10.31-12.29)
0.215
TSPOT
Positive
102 (85.0)
96 (80.0)
6 (5.0)
0.133
Negative
18 (15.0)
15 (12.5)
3 (2.5)
Mtb culture
Positive
78 (65)
70 (58.3)
8 (6.7)
0.158
Negative
42 (35)
41 (34.2)
1 (0.8)
Drug resistance
Yes
32 (26.7)
27 (22.5)
5 (4.2)
0.056
No
88 (73.3)
84 (70.0)
4 (3.3)
The normally and nonnormally distributed continuous variables are indicated as the mean (SD) and median (IQR), respectively. Categorical variables are indicated as frequency and percentage. Differences between groups were evaluated using a 2-sample test (CRP and ESR) or Mann–Whitney test (IL-6). Categorical data were analyzed using the Fisher exact test. TB: tuberculosis; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; IL-6: interleukin-6; ASIA: American Spinal Injury Association; T-spot: TSPOT: T-Spot®.TB; SD: standard deviation; IQR: interquartile range. value < 0.05 was considered statistically significant.
