Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway

<div>Characterization of MDA-MB-231-derived EVs. (a) Expression of exosomal markers in MDA-MB-231-derived EVs was assessed by western blot analysis. “Cells” mean total cellular protein, and “EVs” present small extracellular vesicles. The exosomal fractions are enriched in tetraspanins (CD63 and CD81) and endosomal markers (Alix and TSG101), but do not contain Golgi (GM130) or mitochondrial (cytochrome C) markers. Actin served as a loading control. 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Scale bar represents 200 nm in both panels. (c) Nanoparticle tracking analysis was applied to analyze the size of MDA-MB-231 EVs, representing as size vs. concentration. TSG101: tumor susceptibility gene 101; TEM: transmission electron microscope.</div>

Disease Markers

fig1

Figure 1

Figure 1: Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway 

Figure 1 | Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway 