Integrated Bioinformatic Analysis Identifies TIPIN as a Prognostic Biomarker in Hepatocellular Carcinoma

Figure 1

Integrated analysis of DNA methylation and gene expression profiles in TCGA. Notes: (a) The flowchart of the analysis process on selection of the epigenetically altered driver genes. (b) The cluster map of the mRNA expression of the top 100 genes and top 100 genes with promoter methylation in TCGA cohort. (c, d) Venn diagram of differentially expressed genes and genes with differential promoter methylation. (e) The negative relationship between gene expression and promoter methylation levels in cancer and normal tissues.

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