Research Article

Integrated Bioinformatic Analysis Identifies TIPIN as a Prognostic Biomarker in Hepatocellular Carcinoma

Table 3

Univariate and multivariate analysis of the overall survival of HCC in TMA.

Clinicopathological featuresUnivariate analysisMultivariate analysis
HR95% CI valueHR95% CI value

Age (years)≤551.0001.004-1.1070.0321.0000.979-1.0810.260
>551.0551.029
GenderFemale1.0000.839-15.4730.086
Male3.604
PathogenesisHBV1.0000.564-3.1510.512
Other1.333
ALT (U/L)≤351.0000.259-1.5350.310
>350.631
AST (U/L)≤311.0000.185-1.0830.075
>310.448
TB (U/L)≤121.0000.685-3.6070.286
>121.572
ALB (G/L)≤401.0000.362-2.0790.749
>400.867
TNMI and II1.000
4.536
1.856-11.0860.0011.0001.137-7.8610.026
III and IV2.989
Tumor size≤5 cm1.0000.770-4.0970.178
>5 cm1.776
TIPIN expressionLow1.0001.531-13.0180.0061.0001.079-10.9960.037
High4.4653.444

TIPIN: TIM-interacting protein; ALT: alanine amiotransferase; AST: aspartate transaminase; TB: total bilirubin; ALB: albumin; TNM: tumor node metastasis; HR: hazard ratio; CI: confidence interval; ; .