A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family

Figure 3

3D-structure model of the variant (The FYCO1 protein structure is shown in different color. The location of the mutation p.R471 is marked in red in the green color scheme. The protein structure disruption caused by the nonsense mutation p.R471 is shown in gray. The models are predicted by I-TASSER (include model 1 and model 2). C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence. A indicates a model of correct topology (model 1 ; model 2 ; model 1 )).