TMUB1 Correlated with Immune Infiltration Is a Prognostic Marker for Colorectal Cancer
Table 4
Survival outcomes and multivariate analysis of TCGA data.
Characteristics
Total ()
HR (95% CI)
value
A
T stage (T1 and T2 vs. T3 and T4)
616
0.416 (0.223-0.773)
0.006
N stage (N1 and N2 vs. N0)
615
2.567 (1.787-3.686)
<0.001
M stage (M1 vs. M0)
545
4.096 (2.752-6.096)
<0.001
Age (>65 vs. <=65)
618
2.023 (1.371-2.986)
<0.001
Weight (>90 vs. <=90)
323
0.756 (0.412-1.388)
0.367
Height (> =170 vs. <170)
304
0.773 (0.466-1.282)
0.318
Gender (male vs. female)
618
1.056 (0.744-1.498)
0.762
Race (White vs. Asian and Black or African American)
369
0.933 (0.541-1.610)
0.803
History of colon polyps (yes vs. no)
531
0.832 (0.522-1.326)
0.44
Colon polyps present (yes vs. no)
298
1.316 (0.777-2.229)
0.307
Residual tumor (R1 and R2 vs. R0)
491
4.466 (2.715-7.347)
<0.001
CEA level (>5 vs. <=5)
396
2.697 (1.646-4.418)
<0.001
TP53 status (Mut vs. WT)
526
1.119 (0.768-1.632)
0.558
KRAS status (Mut vs. WT)
526
0.954 (0.657-1.385)
0.805
PIK3CA status (Mut vs. WT)
526
0.892 (0.579-1.375)
0.605
Pathologic stage (stage I vs. stage III, stage IV, and stage II)
598
0.328 (0.153-0.705)
0.004
TMUB1 (high vs. low)
618
1.734 (1.216-2.473)
0.002
B
T stage (T1 and T2 vs. T3 and T4)
616
0.530 (0.067-4.195)
0.548
N stage (N1 and N2 vs. N0)
615
1.362 (0.605-3.065)
0.455
M stage (M1 vs. M0)
545
2.212 (0.846-5.781)
0.105
Age (>65 vs. <=65)
618
2.708 (1.306-5.617)
0.007
Residual tumor (R1 and R2 vs. R0)
491
2.001 (0.880-4.547)
0.098
CEA level (>5 vs. <=5)
396
1.574 (0.802-3.086)
0.187
Pathologic stage (stage I vs. stage III, stage IV, and stage II)
598
0.351 (0.020-6.291)
0.477
TMUB1 (high vs. low)
618
1.960 (1.042-3.686)
0.037
(A) Association with overall survival and clinicopathological characteristics in patients with colorectal cancer using Cox regression. (B) Multivariate survival model after selection of variables.
