TMUB1 Correlated with Immune Infiltration Is a Prognostic Marker for Colorectal Cancer
Table 5
Disease-specific survival and multivariate analysis of TCGA data.
Characteristics
Total ()
HR (95% CI)
value
A
T stage (T1 and T2 vs. T3 and T4)
594
0.157 (0.050-0.500)
0.002
N stage (N1 and N2 vs. N0)
593
4.065 (2.463-6.710)
<0.001
M stage (M1 vs. M0)
524
7.531 (4.683-12.111)
<0.001
Age (>65 vs. <=65)
596
1.468 (0.924-2.332)
0.104
Weight (>90 vs. <=90)
302
1.067 (0.492-2.314)
0.87
Height (> =170 vs. <170)
284
0.821 (0.388-1.734)
0.604
Gender (male vs. female)
596
1.206 (0.768-1.893)
0.415
Race (White vs. Asian and Black or African American)
347
0.493 (0.254-0.959)
0.037
History of colon polyps (yes vs. no)
518
0.988 (0.574-1.698)
0.964
Colon polyps present (yes vs. no)
290
1.386 (0.683-2.811)
0.365
Residual tumor (R1 and R2 vs. R0)
490
6.140 (3.607-10.453)
<0.001
CEA level (>5 vs. <=5)
395
2.889 (1.610-5.187)
<0.001
TP53 status (Mut vs. WT)
504
0.967 (0.595-1.571)
0.891
KRAS status (Mut vs. WT)
504
1.196 (0.739-1.935)
0.466
PIK3CA status (Mut vs. WT)
504
0.928 (0.529-1.629)
0.795
Pathologic stage (stage I vs. stage III, stage IV, and stage II)
577
0.132 (0.032-0.537)
0.005
TMUB1 (high vs. low)
596
2.003 (1.264-3.174)
0.003
B
T stage (T1 and T2 vs. T3 and T4)
594
0.789 (0.098-6.374)
0.824
N stage (N1 and N2 vs. N0)
593
0.833 (0.324-2.140)
0.704
M stage (M1 vs. M0)
524
4.540 (1.574-13.096)
0.005
Residual tumor (R1 and R2 vs. R0)
490
1.727 (0.729-4.093)
0.214
CEA level (>5 vs. <=5)
395
1.676 (0.786-3.574)
0.181
Pathologic stage (stage I vs. stage III, stage IV, and Stage II)
577
0.000 (0.000-Inf)
0.997
TMUB1 (high vs. low)
596
2.538 (1.204-5.350)
0.014
(A) Association with disease-specific survival and clinicopathological characteristics in patients with colorectal cancer using Cox regression. (B) Multivariate survival model after selection of variables.
