Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis

Table 2

GRADE¹ evidence profile for cohort studies on the role of NLR and PLR in poststroke depression.

Certainty assessment							No. of patients		Certainty^7	Importance
No. of studies	Study design	Risk of bias^2	Inconsistency^3	Indirectness^4	Imprecision^5	Publication bias^6	Participants,	Cases,
NLR
7	Observational studies	Not serious	Serious	Not serious	Not serious	None	1831	516	⨁◯◯◯ very low	Critical
PLR
3	Observational studies	Not serious	Very serious	Not serious	Not serious	None	1117	310	⨁◯◯◯ very low	Critical

¹Grading of Recommendations Assessment, Development and Evaluation. ²Risk of bias based on the Newcastle-Ottawa scale. ³When was <30%, inconsistency was considered not serious limitation; when , it was considered serious limitation; and when was more than 75%, it was considered very serious limitation. ⁵Serious limitations were considered when there were fewer than 400 participants for each outcome, and very serious limitations were considered when there were fewer than 300 participants for each outcome. ⁶Funnel plot revealed no asymmetry; neither test of publication bias approached . ⁷Data from cohort studies begin with a grade of “low.” Downgraded for very serious inconsistency. ⁸Data from cohort studies begin with a grade of “low.” Downgraded for serious inconsistency.