Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP

Table 1

Polyphenol extracts from grape seeds, apple, pomegranate, and bilberry facilitate latent HIV transcription.

Agents (200 μM)	GFP-positive cells (%) (J-Lat A2 cells)	GFP-positive cells (%) (2D10 cells)
DMSO	0.6	7.5
Litchi extract	1.2	8.4
Garlic extract	1.0	9.6
Chinese yam extract	1.3	7.5
Grape seed polyphenolic extract	29.6	56.4
Mulberry extract	1.3	6.5
Cinnamon extract	1.4	8.1
Bitter gourd extract	1.6	7.7
Hawthorn extract	1.5	6.3
Apple polyphenolic extract	24.8	60.7
Broccoli extract	1.4	8.9
Pomegranate polyphenolic extract	10.2	30.1
Chrysanthemum extract	1.6	7.0
Chinese date extract	1.6	10.6
Emblic leafflower fruit extract	1.6	11.2
Wolfberry extract	1.8	8.1
Mushroom extract	1.7	8.1
Mint extract	1.7	7.5
Walnut extract	1.6	7.8
Papaya extract	2.0	8.0
Kelp extract	1.8	9.5
Ginger extract	1.6	28.2
Bilberry polyphenolic extract	12.5	15.8
Prostratin-2.5 μM	58.7	93.7