Glaucocalyxin A Attenuates IL-1β-Induced Inflammatory Response and Cartilage Degradation in Osteoarthritis Chondrocytes via Inhibiting the Activation of NF-κB Signaling Pathway

Figure 2

GLA inhibits the production of NO and PGE2 in IL-1β-stimulated OA chondrocytes. Primary human OA chondrocytes were incubated with different concentrations of GLA (0, 5, 10, and 20 μM) for 2 h and then stimulated with IL-1β (10 ng/ml) for 24 h. (a) NO production was evaluated using the Griess reaction. (b) PGE2 content in culture supernatant was determined using ELISA. versus the control group; # versus the IL-1β group.

(a)

(b)