Urolithin B, a Gut Microbiota Metabolite, Reduced Susceptibility to Myocardial Arrhythmic Predisposition after Hypoxia

Figure 4

Urolithin B activates the PI3K/Akt pathway to inhibit hypoxia-induced cardiomyocyte apoptosis and suppressed nuclear translocation of NF-κB to facilitate nerve remodeling. (a–c) Western blotting results and densitometric analysis of p-Akt, T-Akt, p-mTOR, and T-mTOR protein levels in the hypoxia group and the hypoxia+urolithin B group. ; per group (Student’s -test). (d–f) Western blotting results and densitometric analysis of bax and caspase-3 protein levels in the hypoxia+urolithin B and hypoxia+urolithin B+Akti group. ; per group (Student’s -test). (g–i) Western blotting results and densitometric analysis of NF-κB and IkBa protein levels in the hypoxia group and the hypoxia+urolithin B group. ; per group (Student’s -test).

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