Integrated Analysis of the Role of Enolase 2 in Clear Cell Renal Cell Carcinoma

Figure 1

The identification process of ENO2 as the target gene in ccRCC. Notes: (a) intersection of four individual databases (GSE40435, GSE53757, GSE105261, and TCGA) identified 41 genes showing an upregulated pattern in ccRCC tissues. (b) Intersection of the four individual databases (GSE40435, GSE53757, GSE105261, and TCGA) identified 89 genes showing a downregulated pattern in ccRCC tissues. (c) Top 20 key nodes of the 41 upregulated genes based on PPI network. (d) Top 20 key nodes of the 89 downregulated genes based on PPI network. (e) Among the 89 downregulated genes, 29 genes were protective factors. (f) Among the 41 upregulated genes, three genes were risk factors, including ENO2, TGFBI, and TMEM45A.

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