Disease Markers / 2022 / Article / Tab 2 / Research Article
Decreased Preoperative Serum AGR as a Diagnostic Marker of Poor Prognosis after Radical Surgery of Upper Urinary Tract and Bladder Cancers from a Pooled Analysis of 9,002 Patients Table 2 The characteristics of included studies.
Study Study design Country Sample size Tumor Treatment AGR value (high/low) AGR value selection Outcome Median follow-up (months; range) Zhang et al. [28 ] Retrospective study China 187 UTUC Radical nephroureterectomy 1.45 ROC OS; CSS 78 (32-92) Xu et al. [27 ] Retrospective study China 620 UTUC Radical nephroureterectomy 1.45 ROC OS; CSS; RFS 50 (28-78) Fukushima et al. [26 ] Retrospective study Japan 105 UTUC Radical nephroureterectomy 1.24 ROC OS 46 (22-83) Otsuka et al. [25 ] Retrospective study Japan 124 UTUC Radical nephroureterectomy 1.4 ROC OS; CSS; RFS 55 (28-76) Pradere et al. [24 ] Retrospective study Multicenter 172 UTUC Radical nephroureterectomy 1.42 ROC OS; RFS 26 (11-56) Omura et al. [23 ] Retrospective study Japan 179 UTUC Radical nephroureterectomy 1.25 ROC OS; CSS 34 (17-63) Miura et al. [22 ] Retrospective study Multicenter 2492 UTUC Radical nephroureterectomy 1.4 ROC OS; CSS; RFS 38 (NA) Liu et al. [33 ] Retrospective study China 296 BC Radical cystectomy 1.6 ROC CSS; RFS 72 (49.75-115.50) Liu et al. [32 ] Retrospective study China 189 BC Radical cystectomy 1.55 ROC OS; CSS; PFS 38 (1-90) Victor et al. [31 ] Retrospective study Multicenter 4335 BC Radical cystectomy 1.42 ROC OS; CSS; RFS 31.5 (13.3-72.3) Jeong Seok Oh et al. [30 ] Retrospective study Korea 176 BC Radical cystectomy 1.32 ROC CSS; MFS 32.4 (0.2–95.3) Zhang et al. [29 ] Retrospective study China 127 BC Radical cystectomy 1.55 ROC OS; PFS Until March 2018
UTUC: upper tract urothelial carcinoma; BC: bladder cancer; ROC: receiver operating curve; OS: overall survival; CSS: cancer-specific survival; RFS: recurrence-free survival; PFS: progression-free survival; MFS: metastasis-free survival; AGR:
