Linc00312 Single Nucleotide Polymorphism as Biomarker for Chemoradiotherapy Induced Hematotoxicity in Nasopharyngeal Carcinoma Patients

Table 2

Univariate analysis of clinical characteristics and hematotoxicities in NPC patients receiving chemoradiotherapy.

Toxic reactions	Factors	OR (95% CI)
Myelosuppression	pGTVnx
	<71.00 Gy	1 (reference)
	≥71.00 Gy	1.657 (1.096-2.504)	0.017
	IC regimen
	DP	1 (reference)
	FP	0.986 (0.506-1.922)	0.967
	TP	2.549 (1.587-4.093)	<0.001
	GP	5.061 (1.387-18.469)	0.014
	CCRT regimen
	FP	1 (reference)
	TP	4.057 (2.040-8.068)	<0.001
	DDP	1.119 (0.502-2.491)	0.784
	NDP	0.986 (0.489-1.989)	0.969
	DP	1.979 (0.877-4.466)	0.100
Leukopenia	Gender
	Male	1 (reference)
	Female	1.987 (1.180-3.347)	0.010
	Clinical stage
	I-II	1 (reference)
	III-IV	4.437 (1.055-18.673)	0.042
	IC regimen
	DP	1 (reference)
	FP	1.710 (0.816-3.582)	0.155
	TP	2.054 (1.134-3.720)	0.018
	GP	6.351 (1.645-24.512)	0.007
Neutropenia	pGTVnx
	<71.00 Gy	1 (reference)
	≥71.00 Gy	1.949 (1.232-3.084)	0.004
	IC regimen
	DP	1 (reference)
	FP	0.551 (0.230-1.321)	0.182
	TP	2.613 (1.564-4.366)	<0.001
	GP	4.462 (1.179-16.879)	0.028
	CCRT regimen
	FP	1 (reference)
	TP	5.662 (2.478-12.935)	<0.001
	DDP	1.787 (0.699-4.568)	0.225
	NDP	1.266 (0.533-3.006)	0.592
	DP	2.844 (1.094-7.393)	0.032
Anemia	Gender
	Male	1 (reference)
	Female	3.097 (2.048-4.683)	<0.001
	Age
	<47	1 (reference)
	≥47	2.252 (1.565-3.241)	<0.001
	Smoking status
	Smoker	1 (reference)
	Nonsmoker	0.572 (0.401-0.817)	0.002
	pGTVnx
	<71.00 Gy	1 (reference)
	≥71.00 Gy	1.806 (1.265-2.579)	0.001
	IC regimen
	DP	1 (reference)
	FP	1.095 (0.659-1.819)	0.727
	TP	1.653 (1.111-2.460)	0.013
	GP	3.973 (0.997-15.834)	0.051
	CCRT regimen
	FP	1 (reference)
	TP	2.232 (1.248-3.993)	0.007
	DDP	1.780 (0.963-3.292)	0.066
	NDP	0.718 (0.416-1.239)	0.234
	DP	1.599 (0.810-3.156)	0.176
Thrombocytopenia	Age
	<47	1 (reference)
	≥47	2.299 (1.429-3.698)	0.001
	IC regimen
	DP	1 (reference)
	FP	1.571 (0.866-2.853)	0.137
	TP	0.982 (0.587-1.644)	0.945
	GP	4.714 (1.295-17.163)	0.019