Research Article
Linc00312 Single Nucleotide Polymorphism as Biomarker for Chemoradiotherapy Induced Hematotoxicity in Nasopharyngeal Carcinoma Patients
Table 3
Multivariate logistic analysis of candidate SNPs and concurrent chemoradiotherapy induced hematotoxicities in NPC patients.
| | Genotypes | Leukopenia | OR (95% CI) | | Thrombocytopenia | OR (95% CI) | |
(%) |
(%) | Grade 0
(%) |
(%) |
| | rs15734 () | | | | | | | | | | GG | 256 (59.3) | 37 (50.7) | 1.00 (reference) | | 240 (59.0) | 53 (54.1) | 1.00 (reference) | | | GA | 157 (36.3) | 28 (38.4) | 1.155 (0.648-2.058) | 0.626 | 146 (35.9) | 39 (39.8) | 1.295 (0.791-2.122) | 0.304 | | AA | 18 (4.2) | 8 (11.0) | 3.145 (1.123-8.806) | 0.029 | 20 (4.9) | 6 (6.1) | 1.293 (0.473-3.530) | 0.617 | | vs. GG | | | 1.353 (0.787-2.327) | 0.274 | | | 1.295 (0.808-2.075) | 0.283 | | AA vs. | | | 2.986 (1.090-8.178) | 0.033 | | | 1.175 (0.439-3.150) | 0.748 | | rs12497104 () | | | | | | | | | | GG | 145 (33.6) | 29 (39.7) | 1.00 (reference) | | 132 (32.4) | 42 (42.9) | 1.00 (reference) | | | GA | 199 (46.1) | 29 (39.7) | 0.725 (0.397-1.324) | 0.296 | 186 (45.7) | 42 (42.9) | 0.686 (0.411-1.146) | 0.150 | | AA | 42 (9.7) | 9 (12.3) | 0.836 (0.334-2.097) | 0.703 | 45 (11.1) | 6 (6.1) | 0.325 (0.118-0.895) | 0.030 | | vs. GG | | | 0.747 (0.422-1.321) | 0.316 | | | 0.613 (0.373-1.009) | 0.054 | | AA vs. | | | 0.993 (0.418-2.357) | 0.987 | | | 0.399 (0.150-1.060) | 0.065 | | rs164966 () | | | | | | | | | | AA | 249 (57.6) | 37 (50.7) | 1.00 (reference) | | 235 (57.7) | 51 (52.0) | 1.00 (reference) | | | GA | 156 (36.1) | 28 (38.4) | 1.088 (0.609-1.941) | 0.776 | 146 (35.9) | 38 (38.8) | 1.229 (0.746-2.025) | 0.419 | | GG | 23 (5.3) | 8 (11.0) | 2.554 (0.941-6.930) | 0.066 | 24 (5.9) | 7 (7.1) | 1.228 (0.483-3.125) | 0.666 | | vs. AA | | | 1.257 (0.731-2.161) | 0.408 | | | 1.229 (0.765-1.974) | 0.395 | | GG vs. | | | 2.293 (0.885-5.944) | 0.088 | | | 1.135 (0.456-2.827) | 0.785 |
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