Linc00312 Single Nucleotide Polymorphism as Biomarker for Chemoradiotherapy Induced Hematotoxicity in Nasopharyngeal Carcinoma Patients

Table 4

Prediction of the risk of leukopenia in NPC patients based on the interaction between rs15734, gender, and clinical stages.

Clinical factors	Genotypes	Leukopenia		OR (95% CI)
		(%)	(%)
Gender	rs15734 ()
Male	GG	189 (90.4)	20 (9.6)	1.00 (reference)
Male	GA	126 (86.3)	20 (13.7)	1.385 (0.694-2.764)	0.356
Male	AA	14 (73.7)	5 (26.3)	3.876 (1.108-13.563)	0.034
Female	GG	67 (79.8)	17 (20.2)	2.992 (1.412-6.339)	0.004
Female	GA	31 (79.5)	8 (20.5)	2.068 (0.794-5.384)	0.137
Female	AA	5 (62.5)	3 (37.5)	5.635 (1.140-27.857)	0.034
Clinical stage
I-II	GG	30 (96.8)	1 (3.2)	1.00 (reference)
I-II	GA	16 (100.0)	0 (0.0)	—	—
I-II	AA	2 (66.7)	1 (33.3)	18.481 (0.585-584.166)	0.098
III-IV	GG	226 (86.3)	36 (13.7)	10.120 (1.159-88.373)	0.036
III-IV	GA	141 (83.4)	28 (16.6)	11.385 (1.299-99.802)	0.028
III-IV	AA	17 (70.8)	7 (29.2)	25.241 (2.368-269.073)	0.007