Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/<i>β</i>-Catenin Pathway

<div>Pygo1 expression was upregulated in non-small-cell lung cancer. (a) Kaplan-Meier overall survival (OS) curves according to Pygo1 expression levels in database analyzed by Kaplan-Meier Plotter (<span class="nowrap"><svg height="9.51429pt" id="M18" style="vertical-align:-0.2063894pt" version="1.1" viewbox="-0.0498162 -9.3079 59.7019 9.51429" width="59.7019pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M524 0V26C466 32 460 36 460 104V297C460 393 411 449 331 449C302 449 276 437 248 419C223 402 201 387 181 372V451C137 432 90 420 42 411V388C96 378 102 374 102 310V104C102 38 97 33 29 26V0H246V26C187 32 181 36 181 104V339C211 365 250 390 290 390C357 390 381 345 381 276V109C381 40 374 32 315 26V0H524Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.176,0)"><path d="M238 0V26C174 32 166 38 166 104V712C132 700 70 683 18 677V653C81 647 87 645 87 577V104C87 38 78 32 15 26V0H238Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.465,0)"><path d="M257 449C165 449 37 374 37 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(c) Protein expression levels were quantified and analyzed by ImageJ and GraphPad Prism software, respectively. The results shown are representative of independent experiments. (d) Quantitative analysis of IHC images using ImageJ. (e) Representative images from immunohistochemistry (IHC) assays of NSCLC of different pathological grades and adjacent tissues. Grade I, grade II, and grade III refer to WHO-IA-LUAD, WHO-IIA-LUAD, and WHO-IIIB-LUSC, respectively. Scale bar: 100 <i>μ</i>m. ns <span class="nowrap"><svg height="11.7782pt" id="M20" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M531 285V335L57 550V494L473 310L57 127V71L531 285ZM531 -40V10H57V-40H531Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 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Disease Markers

fig1

Figure 1

Figure 1: Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/<i>β</i>-Catenin Pathway 

Disease Markers

Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway

Figure 1