Leptin Promotes HTR-8/SVneo Cell Invasion via the Crosstalk between MTA1/WNT and PI3K/AKT Pathways

Figure 1

Leptin exposure induces HTR-8/SVneo cell invasion. (a) HTR-8/SVneo cells were treated with exogenous leptin (0, 50, 100, 200, and 400 ng/ml) for 24 h, and invasive potential was measured by transwell assay. . vs. leptin (0 ng/ml), vs. leptin (50 ng/ml), and vs. leptin (100 ng/ml); ns: no significance. (b) HTR-8/SVneo cells were treated for 0 h, 12 h, 24 h, and 36 h with 200 ng/ml leptin, and transwell assay was conducted to analyze their invasive potential. . vs. leptin (0 h) and vs. leptin (12 h); ns: no significance. Data are shown as . All experiments were performed in triplicate.

(a)

(b)