Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN

<div>The miRNA expression profile between ADSC-Exos and SC-Exos. (a) The distribution of the differentially expressed miRNAs of ADSC-Exos and SC-Exos in a volcano plot. (b) The top 20 significant KEGG pathway terms sorted by rich factor. (c) Heatmap of 10 miRNAs with high expression in mTOR signaling pathway predicted by sequencing and TargetScan sofeware. (d) Binding sites of miR-22-3p and Pten predicted by TargetScan software. ADSC-Exos, the exosomes extracted from Adipose-derived mesenchymal stem cells; SC-Exos, the exosomes extracted from Schwann cells; miR, miRNA.</div>

Disease Markers

fig4

Figure 4

Figure 4: Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN 

Figure 4 | Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN 