Serum and Cerebrospinal Fluid Testing in Optic Neuropathy Patients with Malignant Tumors

Figure 1

Ophthalmic examination and tissue-based assay of definite paraneoplastic optic neuropathy with lung cancer in Case1. Fundus photograph showed swollen optic disc (a), visual field test showed tunnel vision (b) in the right eye. 2 months after chemotherapy, the edema of optic disc greatly resolved (c) and only small peripheral visual field loss left (d). Unknown serum antineuronal antibody bound to monkey cerebellar Purkinje cells (star, E, F) was detected by tissue-based assay in this patient whose paraneoplastic antibody test result was negative.

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