Research Article
Serum and Cerebrospinal Fluid Testing in Optic Neuropathy Patients with Malignant Tumors
Table 1
Clinical and MRI characteristics, and serum and CSF test results of optic neuropathy patients with malignant tumors.
| | No. | Sex | Age | Eye | BCVA | Ophthalmic examination | Visual field | Orbital/cranial MRI | MCs in CSF test | PA in serum test | ON type | Malignant tumor type | Follow-up (months) | | Initial | Final |
| | 1 | M | 54 | R | 20/100 | 20/25 | Swollen disc | Tunnel vision | Optic nerve enlargement and enhancement | No | No | dPON | Lung cancer | 17 | | L | 20/40 | 20/20 | Swollen disc | Arcuate scotoma | | 2 | M | 58 | R | CF | NLP | Normal disc | Generalized depression | Normal | No | Anti-
Amphiphysin | dPON | Lung cancer | 10 | | L | HM | LP | | 3 | F | 62 | R | 20/200 | 20/60 | Swollen disc | Generalized depression | Optic nerve enlargement and enhancement | No | Anti-CV2 | dPON | Lung cancer | 14 | | L | CF | 20/100 | | 4 | M | 62 | R | 20/25 | 20/200 | Normal disc | Ring scotoma | Optic nerve enlargement and enhancement | No | Anti-CV2 | dPON | Lung cancer | 6 | | L | 20/400 | NLP | Swollen disc | Tunnel vision | | 5 | M | 61 | R | HM | 20/125 | Swollen disc | Generalized depression | Optic nerve enlargement and enhancement | No | Anti-Yo | dPON | Prostate cancer | 8 | | L | 20/60 | 20/40 | Swollen disc | Tunnel vision | | 6 | F | 48 | R | 20/60 | 20/32 | Swollen disc | Peripheral defect | Normal | No | No | dPON | Ovarian cancer | 49 | | 7 | M | 61 | R | 20/200 | 20/40 | Swollen disc | Altitudinal hemiscotosis | Normal | No | No | pPON | Gastric cancer | 55 | | L | 20/100 | 20/32 | Swollen disc | Large cental scotoma | | 8 | M | 54 | R | 20/100 | 20/32 | Swollen disc | Generalized depression | Normal | No | No | pPON | Lung cancer | 20 | | L | CF | 20/200 | | 9 | F | 64 | L | CF | 20/125 | Swollen disc | Generalized depression | Optic nerve enlargement and enhancement | No | No | pPON | Lung cancer | 16 | | 10 | M | 59 | R | 20/20 | 20/20 | Swollen disc | Normal | Normal optic nerve, focal meningeal enhancement | Yes | N.A. | MCON | Gastric cancer | 15 | | L | 20/20 | 20/20 | | 11 | F | 52 | L | 20/20 | 20/20 | Swollen disc and lateral rectus palsy | Normal | Enlarged optic nerve sheath space with sheath enhancement, enlarged cavernous sinus with meningeal enhancement | Yes | N.A. | MCON CSS | Lung cancer | 6 | | 12 | F | 57 | R | 20/50 | 20/40 | Swollen disc
Enlarged SOV | Normal | Enlarged optic nerve sheath space with sheath enhancement, enlarged cavernous sinus with meningeal enhancement | Yes | N.A. | MCON
CSS | Nasopharyngeal carcinoma | 48 | | L | 20/40 | 20/32 | | 13 | M | 37 | L | 20/20 | 20/20 | Swollen disc | Normal | Enlarged optic nerve sheath space with sheath enhancement, focal meningeal enhancement | Yes | N.A. | MCON | Leukemia | 36 | | R | 20/40 | NLP | Swollen disc CRAO | N.A. | Optic nerve enlargement with sheath enhancement, focal meningeal enhancement | Yes | N.A. | ION | | 14 | M | 49 | R | NLP | NLP | Swollen disc CRAO | N.A. | Optic nerve enlargement with sheath enhancement | Yes | N.A. | ION | Lymphoma | 15 |
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BCVA: best corrected visual acuity; R: right; L: left; MCs: malignant cells; CSF: cerebrospinal fluid; PA: paraneoplastic antibody; ON: optic neuropathy; CF: counting fingers; HM: hand motion; LP: light perception; NLP: no light perception; PON: paraneoplastic optic neuropathy; dPON: definite PON; pPON: possible PON; MCON: meningeal carcinomatosis-associated optic neuropathy; CSS: cavernous sinus syndrome; SOV: superior ophthalmic vein; ION: infiltrative optic neuropathy; CRAO: central retinal artery occlusion; N.A.: not applicable.
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