Methylated Septin 9 as a Promising Biomarker in the Diagnosis and Recurrence Monitoring of Colorectal Cancer

Table 2

The values of S9, CEA, and CA19-9 alone and in combination for differential diagnosis of health donors and patients with CRC.

Variable	AUC	Cut-off	Sensitivity	Specificity	95% confidence interval
					Upper limit	Lower limit
S9	0.826	41	72.94%	81.97%	79.15%	86.00%
CEA	0.789	5	43.96%	96.72%	75.13%	82.59%
CA19-9	0.590	37	14.99%	96.61%	53.89%	64.05%
	0.877		78.43%	85.25%	84.88%	90.61%
	0.836		66.91%	91.80%	80.27%	87.01%
	0.788		55.76%	92.62%	75.04%	82.53%
	0.878		78.43%	86.07%	84.89%	90.62%

S9: methylated septin 9 DNA; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen-19-9; CRC: colorectal cancer.