Disease Markers

Research Article

Clinical Significance of Serum Biomarkers in Stage IV Non-Small-Cell Lung Cancer Treated with PD-1 Inhibitors: LIPI Score, NLR, dNLR, LMR, and PAB

Table 3

Univariate and multivariate analyses of biomarkers for PFS and OS.


		PFS				OS
		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value

Gender	Female vs. male	0.679	0.235			0.418	0.021
Gender	Female vs. male	0.359-1.286				(0.199-0.877)
Age	≥70 y vs. <70 y	1.193	0.526			2.093	0.02
Age	≥70 y vs. <70 y	0.692-2.057				(1.125-3.895)
ECOG	≥2 vs. <2	1.323	0.391			1.791	0.186
ECOG	≥2 vs. <2	0.698-2.509				(0.756-4.242)
Smoking	Yes vs. no	1.294	0.332			1.667	0.089
Smoking	Yes vs. no	0.768-2.180				(0.926-3.002)
Histology	LUAD vs. LUSC	0.981	0.942			0.577	0.066
Histology	LUAD vs. LUSC	0.580-1.657				(0.321-1.037)
Stage	IVA vs. IVB	0.786	0.364			0.821	0.507
Stage	IVA vs. IVB	0.467-1.323				(0.458-1.471)
EGFR	Mutant vs. wild	1.253	0.557			0.686	0.339
EGFR	Mutant vs. wild	0.590-2.659				(0.316-1.487)
Liver metastasis	Yes vs. no	1.978	0.12			3.696	0.008	4.714	0.005
Liver metastasis	Yes vs. no	0.838-4.667				(1.396-0.786)		1.562-14.225
Bone metastasis	Yes vs. no	0.713	0.205			0.666	0.175
Bone metastasis	Yes vs. no	0.422-1.203				(0.371-1.198)
Brain metastasis	Yes vs. no	1.063	0.897			0.908	0.854
Brain metastasis	Yes vs. no	0.423-2.673				(0.324-2.544)
Pleural/lung metastasis	Yes vs. no	1.052	0.849			0.967	0.912
Pleural/lung metastasis	Yes vs. no	0.625-1.770				(0.538-1.738)
Other sites	Yes vs. no	0.894	0.678			1.057	0.854
Other sites	Yes vs. no	0.528-1.515				(0.588-1.899)
Line of treatment	≥3 vs. <3	1.646	0.159			0.878	0.719
Line of treatment	≥3 vs. <3	0.823-3.292				(0.432-1.784)
Radiation therapy	Yes vs. no	1.019	0.955			1.011	0.975
Radiation therapy	Yes vs. no	0.535-1.941				(0.511-1.999)
NLR	≥5 vs. <5	0.385	<0.001			1.963	0.027	4.092	0.01
NLR	≥5 vs. <5	0.226-0.656				1.081-3.563		1.407-11.899
dNLR	≥3 vs. <3	3.58	<0.001	2.946	<0.001	3.186	<0.001	5.907	0.001
dNLR	≥3 vs. <3	2.039-6.284		1.615-5.373		1.669-6.082		2.101-16.610
LDH	≥210 vs. <210	1.146	0.611			1.248	0.456
LDH	≥210 vs. <210	0.678-1.936				0.697-2.234
LMR	≥1.8 vs. <1.8	0.367	0.001			0.367	0.001	0.315	0.006
LMR	≥1.8 vs. <1.8	0.206-0.654				0.198-0.678		0.138-0.721
ALB	≥35 vs. <35	0.335	<0.001	0.514	0.033	0.488	0.02
ALB	≥35 vs. <35	0.118-0.596		0.279-0.947		0.267-0.893
PAB	≥17 vs. <17	0.592	0.05			0.467	0.011
PAB	≥17 vs. <17	0.350-1.000				0.259-0.841
LIPI	Good vs. intermediate/poor	2.276	0.019			2.365	0.038
LIPI	Good vs. intermediate/poor	1.146-4.521				1.051-5.325