Identification of the Relationship between Hub Genes and Immune Cell Infiltration in Vascular Endothelial Cells of Proliferative Diabetic Retinopathy Using Bioinformatics Methods

Figure 4

(a, b) Bar plot and heatmap of percentage distribution involved in 24 immune cell infiltrations in all samples. The upper part of the figure revealed the grouping of RECs and FVMs with square bars in different colors. (c) Correlation heatmap of 24 immune cells. The bottom left of the figure depicted the correlation distribution and linear regression between each immune cell subtype and all samples, and the top right described the correlation coefficient value and the value of ( means , reveals , exhibits ). (d) Bean plot. The distribution discrepancies of 24 kinds of immune cell subtypes between RECs and FVMs are exposed. in the figure indicated a significant increase in the FVMs group compared with the RECs group, and implied a significant increase in the RECs group compared with the FVMs group (). (e–g) Lollipop chart. Correlation between the hub genes EEF1A1, RPL11, and RPS27A and 24 kinds of immune cells are, respectively, unshrouded. The size of the dot represented the correlation coefficient between the hub gene and immune cells, and intensity of dot color represents the value. (h) Box plot. Reflected the grouped expression of hub genes EEF1A1, RPL11, and RPS27A in the samples. The bar at the top of the diagram illustrated the value of the difference between groups.

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