Identification of Potential Key Biomarkers and Immune Infiltration in Oral Lichen Planus

Figure 9

ROC curve of the 10 specifically expressed hub genes for OLP. We conducted ROC analysis to evaluate diagnostic performance of 10 specifically expressed hub genes and used area under the curve (AUC) to indicate the intrinsic effectiveness of diagnostic tests. It was showed that SPRR1B had the highest diagnostic value (AUC: 0.837), and other genes AUC were in turn as follows: CDSN (AUC: 0.816), SPRR2G (AUC: 0.796), SPRR2B (AUC: 0.776), PI3 (AUC: 0.755), SPRR2E (AUC: 0.735), S100A7 (AUC: 0.735), LOR (AUC: 0.735), LCE3D (AUC: 0.714), and FLG (AUC: 0.694). Therefore, we hypothesized that SPRR1B might be biomarkers for early diagnosis of OLP.