IDH1 Mutation Induces HIF-1<i>α</i> and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells

<div>Loss of IDH1<sup>mut</sup> suppresses HIF-1<i>α</i> in JJ012 cells and tumor tissues. (a) Immunoblots show HIF-1<i>α</i> expression in JJ012 parental and IDH1<sup>mut</sup> KO cells; immunohistochemical (IHC) images show cytoplasmic IDH1 (b) and nuclear HIF-1<i>α</i> (c) expression in parental and IDH1<sup>mut</sup> KO JJ012-derived xenografts. IHC staining was quantified with intensity scores as detailed in Materials and Methods. Scale bars are 50 <i>μ</i>m. 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Disease Markers

fig2

Figure 2

Figure 2: IDH1 Mutation Induces HIF-1<i>α</i> and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells 

Disease Markers

IDH1 Mutation Induces HIF-1α and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells

Figure 2