Identification of CCL20 and LCN2 as Efficient Serological Tools for Detection of Hepatocellular Carcinoma

Table 2

Performance of individual indicators or combination models in the detection of HCC from comprehensive control.

Indicator	Cutoff^a	AUC^b	S.E.	CI 95	Sens.	Spec.	Accu.
AFP	5.54	0.675	0.028	0.625-0.722	0.743	0.552	0.636
CA199	37.44	0.549	0.030	0.498-0.600	0.293	0.849	0.604
Model_1	0.416	0.667	0.028	0.617-0.714	0.623	0.693	0.662
CCL20	117.08	0.742	0.025	0.695-0.785	0.569	0.811	0.704
LCN2	94.92	0.913	0.014	0.881-0.940	0.743	0.943	0.855
Model_2	0.443	0.927	0.012	0.896-0.951	0.808	0.892	0.859

AUC: area under curve; S.E.: standard error; CI 95: 95% confidence interval; Sens.: sensitivity; Spec.: specificity; Accu.: accuracy. ^aCutoff values were calculated according to maximal Youden index; ^bdifferences between AUCs were compared; significance is showed in Supporting Table 3.