Identification of CCL20 and LCN2 as Efficient Serological Tools for Detection of Hepatocellular Carcinoma

Table 3

Performance of individual indicators or combination models in detection of HCC from liver cirrhosis control.

Indicator	Cutoff^a	AUC	S.E.	CI 95	Sens.	Spec.	Accu.
CCL20	94.53	0.772	0.0295	0.718-0.820	0.683	0.774	0.718
LCN2	94.92	0.898 ^b	0.0179	0.856-0.931	0.743	0.925	0.812
Model_2	0.590	0.919 ^c,d	0.0155	0.880-0.948	0.814	0.868	0.834

AUC: area under curve; S.E: standard error; CI 95: 95% confidence interval; Sens.: sensitivity; Spec.: specificity; Accu.: accuracy. ^aCutoff values were calculated according to maximal Youden index; ^b-dsignificance levels of AUC differences; ^b vs. CCL20; ^c vs. CCL20; ^d vs. LCN2.