Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation

<div>Protein–protein interaction (PPI) network analysis. A network of potential targets of PC with therapeutic effect against HF was visualized using Cytoscape software (a). The top 10 key genes were finally generated by cytoHubba plug-in of Cytoscape (b). Yellow indicates the low degree, while red indicates the high degree.</div>

Disease Markers

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Figure 2

Figure 2: Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation 

Figure 2 | Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation 