Serum Sclerostin and Its Association with Bone Turnover Marker in Metabolic Bone Diseases

Table 7

Univariate logistic regression analysis to explore the relationship between β-CTX and sclerostin and OI, XLH, and PBD.

	OI		XLH		PDB
	OR (95% CI)		OR (95% CI)		OR (95% CI)
β-CTX (per 100 ng/L)	1.344 (1.138,1.588)	< 0.001	1.497 (1.215,1.845)	< 0.001	1.824 (1.148, 2.900)	0.011
Sclerostin (per 50 pmol/L)	2.602 (1.833,3.693)	< 0.001	4.500 (2.653,7.631)	< 0.001	2.166 (1.227, 3.826)	0.008

β-CTX: β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide; OI: osteogenesis imperfecta; XLH: X-linked hypophosphatemia; PDB: Paget’s disease of bone; OR: odds ratio; CI: confidence interval.