Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3⁺ T Lymphocytes, and CEA in Colorectal Cancer Screening

Table 2

Comparison of single and combined detection in CRC screening.

Indicators	AUC^ROC	95% CI		Cut-off value	Sensitivity (%)	Specificity (%)	Youden index
CD3^+ T	0.781	0.728-0.835	<0.001	760	53.48	89.00	0.42
NLR	0.684	0.621-0.747	<0.001	1.95	60.43	70.00	0.30
PNI	0.733	0.674-0.791	<0.001	51.3	71.66	65.00	0.37
D-D	0.805	0.754-0.855	<0.001	89	75.84	76.00	0.52
CEA	0.847	0.804-0.891	<0.001	2.73	70.59	91.00	0.62
Combination	0.943	0.910-0.967	<0.001		84.49	91.00	0.75

AUC^ROC: area under receiver operating characteristic curve; CI: confidence interval.