Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3⁺ T Lymphocytes, and CEA in Colorectal Cancer Screening

Table 4

The relationship between NLR, PNI, D-D, CD3+ T, and CEA levels with clinicopathological characteristics of CRC patients.

Characteristics	CEA (ng/ml)			NLR			PNI			D-D (ng/ml)			CD3^+ T (μL^-1)
	≤2.73	>2.73		≤1.95	>1.95		≤51.3	>51.3		≤89	>89		≤760	>760
Sex
Male	30	86	0.173	41	75	0.131	86	30	0.336	29	87	0.702	66	50	0.311
Female	25	46		33	38		48	23		16	55		35	36
Age (yr)
<63	37	55	0.001	42	50	0.094	63	29	0.342	33	59	<0.001	57	35	0.032
≥ 63	18	77		32	63		71	24		12	83		44	51
Tumor location
Colon	33	64	0.151	37	60	0.678	66	31	0.255	25	72	0.570	84	13	<0.001
Rectum	22	68		37	53		68	22		20	70		17	73
Histological type
Nonspecific adenocarcinoma	54	128	1.000	73	109	0.650	129	53	0.324	44	138	1.000	99	88	0.663
Others	1	4		1	4		5	0		1	4		2	3
Differentiation degree
Well+moderate	46	92	0.048	59	79	0.135	97	41	0.486	39	99	0.024	74	64	0.858
Poor	9	40		15	34		37	12		6	43		27	22
Vascular invasion
Yes	9	35	0.136	18	26	0.836	31	13	0.84	8	36	0.297	27	17	0.263
No	46	97		56	87		103	40		37	106		74	69
Nerve invasion
Yes	12	54	0.013	29	37	0.367	49	17	0.562	16	50	0.966	31	35	0.154
No	43	78		45	76		85	36		29	92		70	51
Tumor size (cm)
< 5	44	88	0.068	59	73	0.026	89	43	0.047	38	94	0.019	70	62	0.677
≥ 5	11	44		15	40		45	10		7	48		31	24
TNM stage
0, I, II	40	60	0.001	35	65	0.170	72	28	0.911	25	75	0.748	55	45	0.771
III, IV	15	72		39	48		62	25		20	67		46	41
T stage
	21	22	0.001	18	25	0.727	31	12	0.942	15	28	0.059	19	24	0.141
	34	110		56	88		103	41		30	114		82	62
Lymph node metastasis
N0	40	61	0.001	36	65	0.234	73	28	0.839	25	76	0.811	56	45	0.670
	15	71		38	48		61	25		20	66		45	41
Distant metastasis
Yes	2	20	0.026	10	12	0.548	17	5	0.534	3	19	0.223	12	10	0.957
No	53	112		64	101		117	48		42	123		89	76