Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15

Figure 2

Analysis of up- and downstream factors of dysregulated lncRNAs in ACS. (a) The network of transcription factors and dysregulated lncRNAs. The yellow circle represents lncRNA, the purple circle represents transcription factor, and the size of the circle represents the degree of transcription factor or lncRNA in the network. (b) The lncRNA-mRNA coexpression network. The yellow circle represents lncRNA, the green circle represents mRNA, and the size of the circle represents the degree of lncRNA or mRNA in the network. The red line represents a positive correlation, and the blue line represents a negative correlation. (c) The network of lncRNAs and their downstream targets. The yellow circle indicates lncRNA, the green circle indicates downstream mRNA, and the size of the circle represents the degree of lncRNA or downstream target in the network. (d–f) The first 30 enrichment results of (d) biological processes, (e) KEGG pathways, and (f) diseases of downstream targets enriched by dysregulated lncRNAs. The rich factor indicates the ratio of input frequency/background frequency, the size of the bubble indicates the number of genes annotated to this function entry for downstream genes, and the color corresponds to the -value.

(a)

(b)

(c)

(d)

(e)

(f)