Inhibition of Galectin-3 Impairs Antifungal Immune Response in Fungal Keratitis

<div>The model of fungal keratitis was established in galectin-3 knockout mice and wild type mice, and anterior segment imaging (a), clinical score (b–d), HE staining (e), two-photon microscopy (TPM) observation (g), and corneal fungal load (CFU) (h) detection were performed. The condition of galectin-3<sup>-/-</sup> mice deteriorated rapidly on the third day after infection compared with the control group. Meanwhile, the number of fungal mycelia in corneas of C57 mice was much more than that of galectin-3<sup>-/-</sup> mice. 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,167.04,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,170.004,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,176.244,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,182.484,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>;</span> NS: no statistical difference.</div>

Disease Markers

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Figure 4

Figure 4: Inhibition of Galectin-3 Impairs Antifungal Immune Response in Fungal Keratitis 