Research Article

The Neuronal Transcription Factor Creb3l1 Potential Upregulates Ntrk2 in the Hypertensive Microenvironment to Promote Vascular Smooth Muscle Cell-Neuron Interaction and Prevent Neurons from Ferroptosis: A Bioinformatic Research of scRNA-seq Data

Figure 4

Ntrk2 upregulation was found to be associated with ferroptosis-related pathways. Correlation analysis of Ntrk2 and ferroptosis-related genes. Ntrk2 expression was found to be significantly correlated with Gpx4 (a). In vascular neurons, Gpx4 expression was found to be positively correlated with Creb3l1 and Ntrk2 (b). RT-qPCR graphs showing the association between Ntrk2 and Gpx4 (c). The potential mechanism of upregulation of Ntrk2 in a hypertensive microenvironment to induce ferroptosis (d).
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