Review Article

Prevalence and Significance of Antinuclear Antibodies in Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

StudyCountryRaceStudy designStudy groupDiagnosis of NAFLD/NASH/NAFLDiagnostic methodsNumber of ANA-positive cases/totalAge, yearsSex (female/male)BMI, kg/m2ALT, U/LAHRQ scale score

Adams 2004 [23]USACaucasianCSAdultNAFLDHistology46/225141/847
Cotler 2004 [12]USACaucasianCSAdultNASHHistology25/7444/30NA8
Yatsuji 2005 [24]JapanAsianCSAdultNAFLDHistology60/200100/100NA10
Banks 2007 [25]USACaucasianCSAdultNAFLDHistology6/2313/10NA10
Niwa 2007 [26] JapanAsianCSAdultNASHHistology35/7146/25NA9
Patton 2008 [27]USAHispanic, CaucasianCSChildrenNAFLDHistology31/17539/13689.89
Boström 2011 [28]SwedenCaucasianCSAdultNAFLDHistology7/5013/37NANA7
Tsuneyama 2013 [29]JapanAsianCSAdultNASHHistology23/5433/21NA8
Younes 2020 [13]Italy, UKCaucasianPCAdultNAFLDHistology156/923293/63010
Zhou 2021 [14]ChinaAsianCSAdultNAFLDHistology50/38898/2909
Yodoshi 2021 [11]USAHispanic, Caucasian,
Black, Asian
CSChildrenNAFLDHistology30/13554/81NA11
Roza 2021 [30]New Zealand, SingaporeAsian, EuropeanPCAdultNASHHistology73/261126/13530.6110
Khayat 2021 [31]USACaucasian, Hispanic, BlackCSChildrenNAFL, NASHHistology46/15248/104NANA9

NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; NAFL: simple nonalcoholic fatty liver; USA: the United States; UK: the United Kingdom; CS: cross-sectional study; PC: prospective cohort study; AHRQ: Agency for Healthcare Research and Quality; BMI: body mass index; ALT: alanine aminotransferase. Values are expressed as . means this article did not report the prevalence of antinuclear antibody positivity but reported the liver related biochemical indexes and histology. means that the data was not recorded directly but could be calculated from the available data according to the following formulas: , . In these formulas, , , and refer to the means, standard deviation, and sample size of each group; the subscript (e.g., 1 and 2) represents different group numbers.