The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2

<div>VAV2 is regulated by tRFdb-3003a and tRFdb-3003b in gliomas. (a) The luciferase reporter assay of glioma cells cotransfected with pmir-RB-VAV2 wild-type or mutant report vector, together with tRFdb-3003a/b mimics or controls. (b) The expression pattens of VAV2 within gliomas of GSE4290 datasets and clinical tissue specimens. (c) Expression levels of VAV2 mRNA (left) and protein (right) in glioma cells transfected with tRFdb-3003a/b mimics or controls. 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Disease Markers

fig7

Figure 7

Figure 7: The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2 