Tumor Suppressor Role and Clinical Significance of the <i>FEV</i> Gene in Prostate Cancer

<div>FEV overexpression disrupts PC-3 cell proliferation, invasion, migration, and cell cycle yet promotes apoptosis in vitro. (a) Enforced expression of FEV in the FEV-stably transfected PC-3 cells verified by western blot and qRT-PCR. (b) Transwell analysis revealed that FEV overexpression disrupted the invasive ability of PC-3 cells. The results of statistical analysis of three independent experiments are shown in panel (c). (d) Wound healing assays showed that FEV upregulation disrupts the migration of PC-3 cells. The results of statistical analysis of three independent experiments are shown in panel (e). (f) CCK-8 assays demonstrated that FEV overexpression impaired proliferative activity of PC-3 cells. (g) Enforced expression of FEV-induced apoptosis of PC-3 cells. (h) Enforced expression of FEV suppressed the cell cycle of PC-3 cells. 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Disease Markers

fig4

Figure 4

Figure 4: Tumor Suppressor Role and Clinical Significance of the <i>FEV</i> Gene in Prostate Cancer 

Disease Markers

Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer

Figure 4